Histology Guide

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MICROGRAPH

NAME

EM 020 Paneth Cells

TISSUE

Small Intestine
(rat)

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5,471 x 4,623 pixels
96 MB

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55,232 KB (color)

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SOURCE

Stanley L. Erlandsen
Department of Genetics, Cell Biology and Development
University of Minnesota
Minneapolis, MN

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Questions or comments should be sent to
tcbrelje@gmail.com

This web site is owned and operated by:

T. Clark Brelje, Ph.D.

Faculty/Retired
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

Robert L. Sorenson, Ph.D.

Professor Emeritus
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

Version 6.0

Copyright © 2005-2024
T. Clark Brelje and Robert L. Sorenson
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EM 020 Paneth Cells

Paneth Cells

Transmission electron microscopy (TEM) of the epithelium at the base of an intestinal crypt, or crypt of Lieberkühn, in the small intestine.

(green) - filled with large, electron-dense secretory granules (purple) clustered near the lumen of the crypt
- Remain at the base of the crypts
- Secrete antimicrobial peptides, such as defensins, and enzymes, such as lysozyme, and phospholipase A2
- Provide crucial signals for maintaining and proliferation of stem cells.
- Long lifespans compared to other intestinal cells
Transit-Amplifying Cells ( and ; tan) - progenitor cells that undergo rapid cell division and differentiate as they move up from the crypt to the villi
- Produce enterocytes, goblet cells, Paneth cells, and enteroendocrine cells
(orange) - narrow, tall cells adjacent to Paneth cells
- Self-renew and produce progenitor cells.
Enteroendocrine Cells ( and ; red) - scattered cells that release hormones into the bloodstream
- Secrete gastrin, cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), or somatostatin
- Important part of the gut-brain axis that regulates digestion, appetite, and metabolism

(light blue) are seen in the lumen of the crypt.

Subcellular Structures

Nuclei (blue) / Nucleolus (yellow) / Nuclear Envelope (purple)
Golgi Apparatus (yellow)
Mitochondria (red)
Endoplasmic Reticulum (cyan)
Secretion Granules (purple)
Lysosomes (black)